Though I would also say this about despair: it is a sin only so long as one can bear the circumstances that precipitate it. Once a person can no longer bear those circumstances, and abandons themself to the whims or caprices of a reality they no longer feel invested in (or cared for or needed by, or equal to meeting), it is no longer despair, but something else, something I would find difficult to characterize or understand, and which perhaps is beyond characterization or understanding, as it would belong to the privacy of each person in their relationship to God.